Flupirtine Maleate is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. It exhibits analgesic and muscle relaxant properties, and protects neurons from excitotoxic, ischemic, or cytokine-mediated death.
- Neuronal potassium channel opener (Kv7 activator).
- NMDA receptor antagonist.
- GABA receptor activator.
- Stabilizes blood-brain-barrier integrity.
- Reduces oxidative stress and brain leukocyte infiltration.
- Enhances angioneurogenesis.
- Suppresses calcium influx.
- Stabilizes neuronal resting membrane potential.
- Counteracts focal cerebral ischemia.
- Functions as a non-opioid analgesic without antipyretic or antiphlogistic properties.
- Shows no relevant affinity to opiate receptor.